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This study builds on the previous work in the identification of critical molecular pathway systems, from a systematic bioinformatics review of C1 metabolism [7] and extends the in silico modeling of C1 metabolism [8] , to incorporate effects of oxidative stress on key biomolecules involved in C1 metabolism

Glutathione is made of 3 different amino acids: cysteine, glycine, and glutamic acid

The recently updated Life's Essential 8 (LE8) metrics, outlined by the American Heart Association (AHA), have demonstrated significant benefits in reducing cardiovascular disease risk and promoting overall cardiovascular health (38)

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Dyslipidemia impacts the function of vascular endothelial cells and vascular smooth muscle cells, thereby promoting the development of atherosclerosis