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The PDI oxidization activity of Ero1L is regulated by an ER redox dependent disulfide bond formation via regulatory cysteines (C104 and C131 in hEro1L) 25,26
Especially, the lung tissue from patients with emphysema has a higher ratio of the number of alveoli/vessels and an increased degree of vessel muscularization
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they are effective only when given before injury, and thereby, less likely to play the role of the endogenous cytoprotective agent in permanent maintenance of the stomach and gastrointestinal tract integrity
J Alzheimers Dis 6:367377
