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Joseph NM, Mosher JT, Buchstaller J, Snider P, McKeever PE, Lim M, et al

Int J Pharmaceutics (2025) 10:100353

Williams CR, Mistry M, Cheriyan AM, Williams JM, Naraine MK, Ellis CL, et al

Wnt ligands bind to Frizzled receptors on the cell surface, resulting in the increased stability of cytoplasmic -catenin, and its subsequent translocation into the nucleus, where it activates the transcription of MITF by interplay with lymphoid enhancer-binding factor 1 (LEF1)/T-cell factor (LEF1/TCF) (26)

PIK3CA mutations are considered an indicator of poor prognosis owing to their association with resistance to chemotherapy 16,17