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doi: 10.1074/jbc.M307146200

Gastroenterology 153, 10401053

N-acetylcysteine is a chemical reducer of disulfide bonds via its free sulfhydryl groups may interact with the extracellular disulfide bridges of angiotensin II receptor, alter its tertiary structure, and inhibit the binding of angiotensin II to its surface receptors (AT 1a receptors) with subsequent attenuation of signal transduction and cell action

The generation of mitochondrial NADPH by NADK2-mediated phosphorylation of NAD + is a critically important reaction that is required for mitochondrial fatty acid synthesis, mitochondrial proline synthesis, regulation of redox status, and overall systemic energy homeostasis

& Walker, S