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Description
DAN can impact various organ systems, including the cardiovascular, gastrointestinal, genitourinary, and sudomotor systems, leading to significant morbidity and mortality among diabetes patients

Feller AG, Rudman D

2021;19(6):e06577

Results From the bibliographic search, 78 articles were related to the select descriptors, but only 15 articles met all inclusion criteria (Figure 1)
Moreover, insulin degrading enzyme (IDE) and biliverdin reductase-A (BVR-A) are the two enzymes associated with insulin signaling that appear to be increasingly oxidized during progression of AD, thus promoting BIR (402, 404406)
