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Hormonal and genetic factors Some labial melanotic macules appear during pregnancy or while taking oral contraceptives, suggesting a hormonal component similar to melasma

Further, elevations in brain glucocorticoid concentrations following chronic alcohol exposure and withdrawal may contribute to the cognitive deficits and neurotoxic damage that are commonly associated with alcohol dependence (Rose et al., 2010)

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MECHANISM OF LOCAL ANESTHETIC TOXICITY Local anesthetics are generally safe and effective when limited to the site of therapy, such as tissue infiltration, near a nerve or a plexus of nerves

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