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Here this group reports a ruthenium-based nanocatalyst alleviating hypoxic TME, activating protein transient receptor potential melastatin 2 ion channel, promoting systemic immune response thereby eliciting its therapeutic efficacy against osteosarcoma.

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The review also highlights the pitfalls of using indirect surrogatessuch as glutathione or cystathionine levelsto infer cysteine availability, which can lead to significant misinterpretation of metabolic states