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doi: 10.1016/S0092-8674(01)00567-0

This has led researchers to explore alternative delivery routes that maximize cellular uptake, stability, and systemic reach, while minimizing degradation

Luchetti and collaborators [135] carried out a multicentric observational study on 377 patients suffering from CTS to evaluate the management practices of this pathology in Italy

These findings suggest that very subtle renal tubular effects may occur under some circumstances, but their clinical significance remains uncertain, especially when no creatinine rise or adverse renal outcome follows

Moving from the N-terminal to the C-terminal region, the protein structure includes seven highly conserved Neh domains [121, 122, 141, 142]