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Transitioning from these cellular findings to the robust identification of these circulating oxidized byproducts (such as 4-HNE, specific epoxy-derivatives, or altered ceramide ratios) in the bloodstream will solve two problems at once: providing a reliable, non-invasive tool to monitor FRDA progression and offering definitive proof of target engagement when testing new anti-ferroptotic drugs

Kernpunt: NAC verhoogt de glutathionniveaus in het lichaam effectiever dan directe glutathionsupplementen, omdat NAC beter wordt opgenomen via de darm

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Extending duration: Acute injuries typically improve within 8-12 weeks

Quercetin can intervene in multiple inflammatory signaling pathways