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10.1016/j.scowo.2024.100014 4 AbuzeidH

This amino acid is also used as the main oxidative fuel to replenish intermediates of the tricarboxylic acid cycle in rapidly dividing cells [1], such as enterocytes and colonocytes [6], fibroblasts, and immune cells such as lymphocytes [7, 8], macrophages, and neutrophils [9,10,11,12]

The MHRA has highlighted that long-term metformin use can reduce B12 absorption, and prolonged use of proton pump inhibitors (PPIs) may also affect B12 status

In the experiment, the hydroalcoholic extract of Black cumin seed is used and phytoestrogens are included in the extract as an active compound of Black cumin

Humans and other eukaryotic organisms lack the enzymatic machinery necessary for de novo Cbl synthesis and rely on external sources, such as diet or symbiotic bacteria, to obtain Cbl [85, 86]