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Most chemotherapeutic agents are generally active in fast-growing cells, including healthy cells
In addition to 30% reduction in lifespan, many abnormalities have been reported for Sod1 / mice including acceleration of age-dependent skeletal muscle atrophy, hearing loss, delayed wound healing, increase in cellular senescence, locomotor defects, denervation, motor axonopathy, impaired motivational behavior, accelerated age-related macular degeneration, impaired olfactory sexual signaling in the male, and lower female fertility (Table S2
Longitudinal change in ventricular volume is accelerated in astronauts undergoing long-duration spaceflight
