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Conversely, 5% of patients receiving clomipramine hydrochloride capsules and 1% receiving placebo had weight losses of at least 7% of their initial body weight

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This is not a trivial consideration

Finally, while sulforaphane is generally well-tolerated at low dose, clinical trials as higher sulforaphane doses can have unwanted side effects, such as lethargy, hypothermia, and gastrointestinal distress, although these generally occur at very high doses (Yagishita et al., 2019)

Moreover, selective depletion of glutathione (GSH) is a defining feature of PD, aligning with the core characteristics of ferroptosis (62) and implicating ferroptosis as a potential driver of dopaminergic neuron loss