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Mutations in genes crucial for LRO biogenesis are implicated in several inherited rare disorders developing co-existing symptoms of hypopigmentation, immunodeficiency, bleeding diathesis, and neuropathy (e.g., Hermansky-Pudlak Syndrome, Chediak-Higashi Syndrome, Griscelli Syndrome) 4,5

Keywords: trimethylamine N-oxide, gut-organ axis, cell death, biomarker, therapeutic strategies Introduction The gut is a vital organ of the host

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