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One of the triggers of Ca 2+ release from the brain mitochondria can be perisynaptic ATP bound to astrocyte receptors

Multiple daily doses : Due to shorter effective duration from lower peak concentrations, oral protocols sometimes split the daily dose into 2-3 administrations to maintain more stable levels

The study provides a specific targeting technique for colorectal cancer and can also be implemented in other cancers as a complex nanotheranostics technique that accounts for TME reprogramming ( As discussed previously, a plethora of research studies elaborating on different forms of nanodelivery system developed for cancer nanotheranostics have been conducted

In that manner, NMOSD could also be called an astrocytopathy, along with GFAP-IgG autoimmune encephalitis (90)

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