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Description
doi: 10.1007/s00424-009-0677-8
Currently it is unknown under what conditions (if any) it is safe to use MOTS-c because there are no completed clinical trials

These movements will result in pain if the sciatic nerve is affected

Published research (Stoeva MK et al., Gut Microbes, 2021) on Clostridium butyricum confirms it is a direct butyrate-producing organism in the gut
The LactMed database reports minimal transfer into breast milk, and it has decades of safety data in lactating women
