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Apoptosis is a process of programmed cell death that can contribute to pathological cell and tissue damage in cardiovascular and neurodegenerative diseases, and during the response to toxins (including chemotherapeutic agents), sepsis, or other environmental and physiological stimuli

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These included Laminin Subunit Alpha 1 ( LAMA1 ), Fibronectin 1 ( FN1 ), and Laminin Subunit Beta 1 ( LAMB1 ), as well as ECM signaling regulators, including Cadherin 1 ( CDH1 ), Cadherin 2 ( CDH2 ), and Glypican 3 ( GPC3 ) (Fig