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doi: 10.1371/journal.pone.0145038

10.2147/JHC.S335425 Summary Keywords hydrogen sulfide, hepatocellular carcinoma, apoptosis, cystathione gamma-lyase, 3-mercaptopyruvate sulfurtransferase Citation Zhao H, Zhang Y, Fu X, Chen C, Khattak S and Wang H (2023) The double-edged sword role of hydrogen sulfide in hepatocellular carcinoma
Currently, a limited number of iron chelators have received approval from the FDA or are undergoing clinical trials for conditions such as iron overload-related diseases, organ damage, and transplants (Ballas et al., 2018)

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According to the proposed mechanism, Gln consumption by ccRCC tumor cells leads to local depletion of extracellular matrix Gln, thereby activating the HIF1/IL-23 signaling pathway in tumor-infiltrating macrophages