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Because a delay in providing therapy can lead to irreversible neurological dysfunction, advanced conservative therapy is strongly recommended in patients with BPI

Neuropathy scores improved in seven patients, mostly in patients with immune-mediated neuropathy, but remained unchanged or worsened in the remaining five patients (two patients dropped out due to adverse events that were considered unrelated to B12)

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Food and Agriculture Organization of the United Nations, Rome Hayashi K, Kasza KE (2001) Ice slurry cooling research: effects of microscale ice particle characteristics and freezing-point-depressant additives on ice slurry fluidity/discussion