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doi: 10.1016/j.lfs.2022.120333

According to the National Institutes of Health (NIH), it is also naturally produced in the human liver, kidneys, and brain

doi: 10.1186/s12970-018-0247-6 Harty, P., Zabriskie, H., Erickson, J., Molling, P., Kerksick, C., & Jagim, A

Caffeine may act on other hormones and neurotransmitters of the brain like dopamine and adrenaline and it may constrict blood flow to the brain too

Possible mild gastrointestinal discomfort
