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Ofengeim, D

Acknowledgments The authors sincerely thank the Department of Product Evaluation (Shanghai Jiyan Biomedical Development Co., Ltd.) for their technical support in skin experiments

They categorized results according to having a high pesticide exposure event (HPEEs), with those individuals who have ever experienced an HPEE ( n = 142), associated with hypermethylation of the GSTP1 promoter and loss of methylation at the MGMT promoter, with greater effects observed in applicators of more advanced age and with lower plasma folate levels

The rate-limiting step in the de novo synthesis of the GSH is catalyzed by gamma-glutamyl-cysteine synthetase (also known as glutamine-cysteine ligase), which is a target gene of Nrf2
