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95% of cases of genetic defects in glycolytic enzymes is caused by pyruvate kinase deficiency

We order vitamin B12 and folate testing when a person with Down syndrome we are evaluating has symptoms described above, has a lab abnormality for which follow up testing of vitamin B12 and/or folate is indicated, or the person has a condition in which deficiency is common (e.g., celiac disease)

Christgen S, Tweedell RE, Kanneganti TD

3.1 The microbiotagutbrain axis In recent years, the microbiotagutbrain axis (MGBA) has received significant attention in the study of AD