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Gastroenterology 111 : 638-647
Unlike the approved PDE5-Is, its PDE5 inhibitory activity was found to be against the full-length enzyme but not the PDE5 catalytic domain, indicating that its activity is strictly dependent on the presence of PDE5 regulatory domain, giving promise to develop a class with higher selectivity than the conventional PDE5-Is [261]
Conversely, Nrf2 inhibition blocks antioxidant gene activation, resulting in ROS accumulation, macromolecular damage, and cell death
The volume was then adjusted to 50 mL with 95% ethyl alcohol to create a stock solution
B., Buring, J
