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Other Nrf2 activators, such as GSK3 inhibitors, may have adverse side effects by affecting other signaling and metabolic pathways

The mechanism involves NAD+-dependent enzymes critical for glucose metabolism

Collectively, these findings suggest that distinct HIF subtypes are expressed in various synovial cell types, all of which participate in the occurrence and progression of RA

Aside from the anticipated vascular results, the data also revealed immune-mediated brain accumulation of the micelles across the BBB [96]

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