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Furthermore, NPs can be engineered to mimic endogenous transport mechanisms, like those used by nutrients or hormones, to cross the BBB more effectively (22)
Tirzepatide has a half-life of approximately 5 days, with elimination occurring over several weeks
10.1016/S0969-2126(00)00510-4
Biosimilar investment cases should model PTAB success as a probability-weighted acceleration of LOE dates, and that probability should reflect the 94% rate at which biologic patents do not walk away from PTAB with all claims intact
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