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Manassas, VA, USA) and grown in Dulbecco's modified Eagle's medium (DMEM) supplemented with 10% (v/v) fetal bovine serum (FBS), 100 units/mL penicillin, and 100 mg/mL streptomycin in a humidified atmosphere of 95% air and 5% CO 2 at 37C

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While studies have shown that cAMP signaling has both inflammatory and anti-inflammatory effects, in myeloid cells, cAMP signaling is largely associated with a decrease in inflammation (Serezani et al., 2008

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Due to their delivery route, oral peptides, like Healthletic's Arginine Salt formulation, are often highlighted for this type of support