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Conclusion: Previously reported LAAS-related genetic variants may have an indirect effect on sICAS pathogenesis, e.g., rs112735431 associated with a spectrum of stroke risk factors and rs2107595 polymorphism correlated with stroke mechanisms
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A response that fails to acknowledge the issues or appears argumentative raises serious concerns

doi: 10.1111/j.1530-0277.2002.tb02543.x
