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Specifically for NAC, the reduction in mortality (odds ratio 0.56, 95 % confidence interval 0.470.67) remained significant in a multivariate analysis adjusted for baseline characteristics and concomitant use of corticosteroids

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Yet, preterm infants appear to be especially vulnerable to adverse effects of -tocopherol supplementation, and supplemental vitamin E should be administered only under controlled supervision by a pediatrician (122)