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In breast cancer, CHAC1 overexpression promotes both proliferation and migration, while in ovarian cancer, its impact is primarily restricted to cell migration, with minimal effect on proliferation (Goebel et al., 2012)

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described the first condition of IGF-I deficiency as a new type of dwarfism indistinguishable from genetic isolated GH deficiency, but with unexpected high serum GH levels[199, 200] and inability to synthesize IGF-I and other related molecules, as IGFBP-3[34, 35, 201]