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The study identified two noteworthy metabolomic markers, tyramine and mucic acid, as relevant to the pathogenesis of both psoriasis and its arthritis subtype (123)

[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes

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Its activation is a protective response against oxidative stress, as it helps to degrade heme, a pro-oxidant molecule, and generates products like biliverdin, which possess antioxidant properties HO-1 expression is regulated by the transcription factor, Nrf2, which activates antioxidant response elements (AREs) in the promoter region of the HMOX1 gene, encoding HO-1 (Chiang et al., 2021