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Historically the use of copper ionophores such as PBT2 have failed to produce efficacious results in clinical trials (Summers et al., 2022), but crucially they have been investigated without the addition of copper, probably due to the theory that it was primarily to disaggregate copper loaded plaques, in which case PBT2 would act as a chelator (Drew, 2017)

10.1136/gut.2007.140806 Gut

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Although we were unable to confirm the regression of TLS due to the lack of rebiopsy, together with the previous reports indicating that steroid treatment reduces the size of TLS and that the presence of TLS is correlated with increased proteinuria in IgA nephropathy patients, these findings possibly suggest that urinary GSH levels may reflect the resolution of TLS in certain subpopulations of IgA nephropathy patients