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In Phase 2 clinical trials, researchers observed dose-dependent effects on body weight and appetite measures, with concomitant increases in heart rate attributable to peripheral noradrenergic effects

The irreversible electrical coagulation of the distal segment of the left middle cerebral artery was performed under anesthesia with chloral hydrate (300 mg/kg)

However there are problems with corticosteroids

Across hundreds of animal studies, serious adverse effects have not been commonly reported