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Disorders Associated with Tetrahydrobiopterin Synthesis and Salvage There are at least four identified disorders that manifest with BH 4 -deficient hyperphenylalaninemia designated as hyperphenylalaninemia, BH 4 -deficient type A (HPABH4A), HPABH4B, HPABH4C, and HPABH4D

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Insert the needle at a 45- to 90-degree angle in a quick, smooth motion