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Diagram illustrating how lowdose methotrexate increases intracellular ATP/ADP, leading to enhanced extracellular efflux, resulting in conversion to adenosine via CD39 and CD73
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J Calcif Tissue Int
88 Although cisplatin can have a similar effect at a much lower dose (8 mg kg 1 ) this latter value approached the MTD (13 mg kg 1 )
