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A high-fat diet increases intestinal DCA levels, and DCA promotes the expression of HIF- 2 and DMT1, leading to the accumulation of ferrous ions in IECs and the onset of ferroptosis [12]

doi: 10.1016/j.fct.2009.10.030

The mobile phase consisted of water, 0.1% formic acid and methanol at a flow rate of 1 mL/min

Furthermore, it has been shown that the substrate binding step has been proven to be particularly important in determining the catalytic efficiency of the enzyme

For instance, oxidative stress regulates the expression of intercellular adhesion protein-1 (ICAM-1), a cell surface protein in endothelial and epithelial cells, most likely due to the activation of NF-B