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Description
1993;53(18):PL291PL296

The pathogenesis of OA is highly complex, involving interactions among multiple factors such as abnormal mechanical loading, age-related metabolic changes, persistent inflammatory responses, dysregulated extracellular matrix(ECM) metabolism, and genetic susceptibility

[DOI] [PMC free article] [PubMed] [Google Scholar] Sandyk R, Kanofsky JD

This is relevant to ANCA-associated vasculitis, where anti-MPO autoimmunity can be driven by TLR9-mediated DC activation 47 , and to nonalcoholic steatohepatitis (NASH), in which hepatocyte mitochondrial DNA triggers liver inflammation through TLR9 activation in proinflammatory cells, including neutrophils 48

Results vary by individual.
