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5785, doi:10.1016/B978-0-12-380866-0.60003-4, ISBN 978-0-12-380866-0, PMID 20920745, retrieved 2021-12-03 "Histone Modifications and Cancer"

[] To meet their rapid growth requirements, cancer cells undergo metabolic adaptations to survive under multiple stressful conditions such as hypoxia and nutrient deprivation
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Higher HbS concentrations increase the probability that aggregation and polymerization will occur during any given period of deoxygenation
