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doi: 10.1016/j.jneumeth.2023.109931

3 RGN-259 Phase 3 Trial in Neurotrophic Keratopathy Sosne et al., International Journal of Molecular Sciences (2022) This Phase 3 randomized, placebo-controlled, double-masked clinical trial evaluated topical 0.1% RGN-259 (full-length recombinant T4 ophthalmic solution) in patients with neurotrophic keratopathy

DSIPs profile suggests a different, more physiology-aligned mechanism Other peptides (Epitalon, Semax, BPC-157) broader systemic effects

In addition, HHAs are small entities, as that is the term used in the RFA

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