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Gamma-secretase cleavage takes place in the membrane-spanning domain of the APP protein

Chemosphere 119(1):668674 Suchail S, De SG, Rahmani R, Rahmani R, Belzunces LP (2004a) In vivo distribution and metabolisation of 14C-imidacloprid in different compartments of Apis mellifera L

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NAD+ levels in human skin decline with age, and this decline affects multiple repair mechanisms simultaneously: DNA repair capacity (through PARP enzyme activity), mitochondrial energy production in skin cells, autophagy of damaged proteins, including glycated collagen, and the sirtuin-mediated preservation of collagen integrity

Metrics including (1) normalized TF expression in RG, (2) scaled TF motif accessibility and target gene expression in RG, (3) predicted eGRN sizes, (4) cell-type specificity (RSS) of eGRNs and (5) predicted transcriptomic consequences in the RG lineage were used to select TF targets for this study (Supplementary Table 1)