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The polymer backbone covalently integrates an L-buthionine sulfoximine prodrug to inhibit glutathione biosynthesis, and the nanoparticle matrix encapsulates an elesclomol-copper complex to promote intratumoral copper accumulation

Abstract Liver sarcoidosis is usually an underdiagnosed disease, which can have severe implications in the evolution of a patient

Since our RNA-seq and ChIP-seq analyses indicated that increased glutamine levels repressed the global expression of melanoma-related oncogenes, we sought to test whether glutamine supplementation can cooperate with current targeted therapies

Kieliszek M, Blazejak S