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Intracellular iron is stored in two major formsan unstable intracellular free ferrous iron pool and an inert form bound to ferritin ( 2 can trigger the Fenton reaction, producing ROS ( 4.2.2 Iron metabolism Transferrin-bound trivalent iron binds to the transferrin receptor (TFR1), allowing direct cellular entry through endocytosis and converts it to ferrous iron through STEAP3