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Under oxidative stress (such as UV and other stimuli), P53 was activated in keratinocytes, and keratinocytes synthesized higher levels of SCF, ET-1, POMC, and -MSH to promote melanin generation

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Baseline and on-treatment measurements would provide evidence of whether oxidative stress is actually elevated and whether intervention helped

Icariin protects against iron overload-induced bone loss via suppressing oxidative stress

Elevated intra-articular iron levels and altered expression of ferroptosis-related molecules such as ACSL4 and GPX4 have been associated with the severity of joint pain, cartilage damage, and functional decline (5860)