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In the cytosol and nucleus, several enzymes create localized ROS microdomains: xanthine oxidoreductase (interconverting XDH and XO) at cytosolic and endothelial surfaces, monoamine oxidases on the outer mitochondrial membrane facing the cytosol, dihydrolipoamide dehydrogenase within the PDH/OGDH complexes and NOX isoforms positioned at the nuclear envelope (Moloney et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 127.Greiner R, Palinkas Z, Basell K, Becher D, Antelmann H, Nagy P, Dick TP

The treatments were delivered either as continuous systemic infusion via an intra-arterial cord catheter until P5 or subcutaneously three times daily until P9

The GTPase superfamily: conserved structure and molecular mechanism

10.1016/j.biopha.2018.11.030 Biomed Pharmacother