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Liver fibrosis represents, together with the comorbidities of metabolic syndrome, a significant prognostic determinant in NAFLD

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Each animal was inoculated by subcutaneous injection of 2 10 6 HT-29 cells mixed with 1 10 6 freshly isolated human PBMCs, cells were mixed 1:1 v/v with LDEV-free extracellular matrix protein Geltrex (Gibco, # A1413201) and inoculated in the right flank under anaesthesia

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The final residue-level states were aggregated by masked sum pooling (Equation 5):where denotes the sequence length of peptide and is the validity mask for residue