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doi: 10.1093/annonc/mdl176 167 DengLZhangHLuanYZhangJXingQDongSet al

Nielsen C, Gormsen LC, Jessen N, et al

Santiago, CL

Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion

In addition to blocking NMDARs, Pb 2+ toxicity manifests as an inhibitory effect on the transport of sodium, calcium, and other ions through the membrane, thus suppressing the excitatory postsynaptic potential, which in turn may limit the generation of action potentials (Flora et al
