how long have glp 1 drugs been around GLP-1 and Type Diabetes: Less Insulin, Better Time in Range — What the Evidence Upgrading from Overweight: The Effects

Fratiglioni L, Launer LJ, Andersen K, Breteler MM, Copeland JR, Dartigues JF, et al

R&D and Innovation: Pharmaceutical companies are continuing to invest in the development and innovation of GLP-1RA drugs that should lead to increased efficacy, further use cases and reduced side effects

Vasodilatory effect Studies showed that GIPR and GLP1R are present in the smooth muscle cells and endothelial arterioles and may have a cardioprotective effect due to endothelium-dependent vasodilation [105]

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Effects of Glucagon Like Peptide-1 Receptor Agonists on the Neurological System Autoradiography of human tissue sections with 125 I-labelled GLP-1 (7-36 amide) revealed a high content of GLP-1R in the central nervous system suggesting its potentially important role in the nervous system (28)