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In the original mathematical model four biomarkers are combined: serum holoTC, serum B12, serum methylmalonic acid (MMA), serum homocysteine (Hcy) to yield a combined indicator termed the cB12 or 4cB12
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Notably, the bell-shaped doseresponse profiles seen in this Met dimerization assay with both dimeric macrocycles and hHGF (Supplementary Fig
H., Pettersen, E
every 4 days for 28 days Result:Showed antitumor efficacy in tumor xenografts
