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New England Journal of Medicine 2018;378
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As shown in the Table above there are three known polymorphisms in the ADH1B gene and two in the ADH1C gene

Nicotine affects the functional activity of ion transporters, including Na + , K + , 2Cl cotransporter and Na + , K + -ATPase on BECs and inhibits P-gp activity in the CNS (Paulson et al., 2006

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