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Description
Plasma concentrations measure around 200 ng/mL at age 20 and drop to roughly 80 ng/mL by age 60 a decline of more than 60%
Morikawa, S

Pharmacokinetic and pharmacodynamic evaluation of the drug-drug interaction between isavuconazole and warfarin in healthy subjects

Journal of Applied Physiology , 109(5), 13721378

Based on the available evidence, it appears that rmTBI can result in a progressive accumulation of damage, manifesting as behavioral symptoms, neuropathological changes, and neurodegeneration
