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(2015), based on 15 years of clinical observation, concluded that frequent, high-dose administrations of vitamin B12 injections, in combination with oral folic acid, may respond favorably in alleviating the profound fatigue and cognitive dysfunction seen in ME/CFS patients

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doi: 10.1038/s42255-025-01340-8, [DOI] [PMC free article] [PubMed] [Google Scholar] Weiduschat N., Mao X., Hupf J., Armstrong N., Kang G., Lange D