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POMC, pro-opiomelanocortin
2019 ESC Guidelines on diabetes, prediabetes, and cardiovascular diseases developed in collaboration with the EASD

Nevertheless, current evidence supports GLP-1 RAs and multi-agonist formulations as highly promising pharmacotherapies that address the complex, multifactorial pathophysiology of MASLD while simultaneously improving cardiometabolic comorbidities, positioning them as cornerstone treatments in the evolving therapeutic landscape for this prevalent and burdensome disease

Still in Phase 3 clinical trials, early results show unprecedented weight loss, with some participants losing over 24 percent of body weight

The first dose experience varies from person to person, but understanding what to expect helps manage initial side effects
